Lupe, head of a Latinx punk rock band, discovers only her piercing musical scream can stop an alien invasion. She and her bandmates become the target of two warring alien races hellbent on destroying each other, and taking planet Earth down with them. With the help of Lupe’s sweet, shotgun-toting Abuela, Pachi, and her high-powered, socialite mother Karen, the gang of misfits do all they can to save the world.