At the birth of two boys, one white and one black, a mysterious and powerful Conjure Woman (Maya Angelou) prophesies that they will start the change. Growing up as best friends in rural Georgia in the 1940s, the boys make a discovery that leads the town's new sheriff, Frank Richards (Dean Cain), to reopen the investigation of the unsolved murders of three black men. While the town would prefer that the truth remain hidden, the sheriff pursues the case, determined to see justice prevail. The Runaway is a stirring story of how friendship, determination and conviction can generate racial change in one heart or an entire town.