After living with her grandparents, young Sneha is relocating to live with her father Hareendran and her step-mom Anjali, a trans woman, who extends her love and care for Sneha. Sneha understands more about Anjali and becomes in awe of the life the latter has been leading. The film focuses on the plight of a trans woman who had to live as a wife of an ordinary man. ‘Antharam’ deals with the inner conflicts, warmth, trauma and joyous moments in the lives of a trans woman, a woman and a man living under the same roof.